DLR - Institut für Luft- und Raumfahrtmedizin - Jochen Zange, Institut für Luft- und Raumfahrtmedizin

Sie sind hier: Home:Institut:Mitarbeiter

Mitarbeiter

(13.02.2008)

Dr.rer.nat. Jochen Zange

Dr.rer.nat. Jochen Zange
Leiter der Arbeitsgruppe Integrative Muskelphysiologie

Deutsches Zentrum für Luft- und Raumfahrt (DLR)
Institut für Luft- und Raumfahrtmedizin
Weltraumphysiologie
Linder Höhe
51147 Köln

Telefon:+49 2203 601-3456
Email:Jochen Zange
Internet:http://www.dlr.de/me

Ausbildung:
Studium der Biologie an der Universität Düsseldorf (1979 - 1985)

Diplom in Biologie:
1985: Universität Düsseldorf, Fächer: Zoologie, Pflanzenphysiologie, Organische Chemie

Dr. rer. nat. in Biologie:
1990, Heinrich-Heine-Universität Düsseldorf

Venia legendi (Privat-Dozent) in Physiologie:
2006, Medizinische Fakultät Universität zu Köln

Berufslaufbahn:

1988 - 1990	Wissenschaftlicher Angestellter am Max-Planck-Institut für Systemphysiologie, Dortmund
1990-1991	Wissenschaftlicher Angestellter am Institut für Zoologie, Lehrstuhl für Tierphysiologie, Heinrich-Heine-Universität Düsseldorf
seit 1991	Wissenschaftlicher Angestellter am Institut für Luft- und Raumfahrtmedizin, Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR), Köln

Forschungsinteressen:

Physiologie und Pathophysiologie der menschlichen Skelettmuskulatur, Nicht-invasive Untersuchungen zur Kontraktilität, zum Energiestoffwechsel, zur Durchblutung und Elektrophysiologie, Entwicklung und Validieren von „Countermeasures“ gegen Muskelschwäche durch Nahrungsergänzung und optimiertes Training.

Publikationen:

Zange, J., Haller, T.,Müller, K., Liphardt, A.-M., Mester, J.: Energy metabolism in human calf muscle performing isometric plantar flexion superimposed by 20-Hz vibration, Eur. J. App. Physiol. 105(2): 265 - 270 (2009)
Zange, J., Mester, J., Heer, M., Kluge, G., Liphardt, A.-M.: 20-Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6° head down tilt bed rest, Eur. J. App. Physiol. 105(2): 271 - 277 (2009)
Zange, J., Beisteiner, M., Müller, K., Shushakov, V., Maassen, N.: Energy metabolism in intensively exercising calf muscle under a simulated orthostasis. Pflügers Arch. 455 (6): 1153-1163 (2008)
Vorgerd, M., Zange, J.: Treatment of glycogenosys type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with 31P-MRS on working leg muscle. Acta Myol. 26: 59-61 (2007)
Grehl, T., Fischer, S., Müller, K., Malin, J.P., Zange, J.: A prospective study to evaluate the impact of 31P-MRS to determinate mitochondrial dysfunction in skeletal muscle of ALS patients. Amyotroph. Lateral. Scler. 8(1), (2007), 4-8. (2007)
Schroers, A., Kley, R.A., Stachon, A., Horvath, R., Lochmüller, H., Zange, J., Vorgerd, M.: Gentamycin treatment in McArdle disease: Failure to correct myophosphorylase deficiency. Neurology 66, 285-286 (2006)
Kornblum, C., Schröder, R., Müller, K., Vorgerd, M., Eggers, J., Bogdanow, M., Papassotiropoulos, A., Fabian, K., Klockgether, T., Zange, J.: Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study. Eur. J. Neurol, 12, 300–309 (2005)
Saft, C., Zange, J., Andrich, J., Müller, K., Lindenberg, K., Landwehrmeyer, B., Vorgerd, M., Kraus, P.H., Przuntek, H., Schöls, L.: Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease. Mov. Disord., 20(6), 674-679. (2005)
Schöls, L., Zange, J., Abele, M., Schillings, M., Skipka, G., Kuntz-Hehner, S., Van Beekvelt, M.C., Colier, W.N., Müller, K., Klockgether, T., Przuntek, H., Vorgerd, M. L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial. J. Neural. Transm., 112(6), 789-796. (2005)
Zange, J., Grehl, T., Disselhorst-Klug, C., Rau, G., Müller, K., Schröder, R., Tegenthoff, M., Malin, J.P., Vorgerd, M.: Breakdown of adenine nucleotide pool in fatiguing skeletal muscle in McArdle’s disease: a non-invasive 31P MRS and EMG study. Muscle Nerve, 27,728-736. (2003)
Klasing, M., Zange, J.: In vivo quantitative near-infrared spectroscopy in skeletal muscle and bone during rest and isometric exercise. Proc. SPIE, in press (2003)
Zange, J., Kornblum, C., Müller, K., Kurtscheid, S., Heck, H., Schröder, R., Grehl, T., Vorgerd, M.: Creatine supplementation results in elevated phosphocreatine/adenosine triphosphate (ATP) ratios in the calf muscle of athletes but not in patients with myopathies. Ann. Neurol., 52,126-127. (2002),
Vorgerd, M., Zange, J., Kley, R., Grehl, T., Hüsing, A., Jager, M., Müller, K., Schröder, R., Mortier, W., Fabian, K., Malin, J.P., Luttmann, A.: Effect of High-Dose Creatine Therapy on Symptoms of Exercise Intolerance in McArdle Disease: Double-blind, Placebo-Controlled Crossover Study. Arch. Neurol., 59,97-101. (2002)
Vorgerd, M., Zange, J.: Carbohydrate oxidation disorders of skeletal muscle. Curr .Opin. Clin. Nutr. Metab. Care, 5, 611-617
(2002)
Schöls, L., Vorgerd, M., Schillings, M., Skipka, G., Zange, J.: Idebenone in patients with Friedreich ataxia. Neurosci.Lett., 306, 169-172 (2001)
Christ, M., Zange, J., Janson, C.P., Müller, K.,. Kuklinski, P., Schmidt, B.M.W., Tillmann, H.C., Gerzer, R., Wehling, M.: Hypoxia modulates rapid effects of aldosterone on oxidative metabolism in human calf muscle. J. Endocrinol. Invest., 24, 587-597. (2001)
Ziemssen, F., Sindern, E., Schröder, J.M., Shin, Y.S., Zange, J., Kilimann, M.W., Malin, J.P., Vorgerd, M. Novel missense mutations in the glycogen branching enzyme gene in adult polyglucosan body disease (APBD), Ann. Neurol., 47, 536-540. (2000)
Vorgerd, M., Schöls, L., Hardt, C., Ristow, M., Epplen, J.T., Zange, J.: Mitochondrial impairment of human muscle in Friedreich ataxia in vivo. Neuromuscul. Disord., 10, 430-435 (2000)
Vorgerd, M., Grehl, T., Jäger, M., Müller, K., Freitag, G., Patzold, T., Bruns, N., Fabian, K., Tegenthoff, M., Mortier, W., Luttmann, A., Zange, J., Malin, J.P.: Creatine Therapy in Myophosphorylase Deficiency (McArdle Disease): A Placebo-Controlled Crossover Trial. Arch. Neurol., 57, 956-963. (2000)
Baerwalde, S., Zange, J., Müller, K., Maassen, N.: High-energy-phosphates measured by 31P-MRS during LBNP in exercising human leg muscle. J. Gravitat. Physiol., 6, P37-P38. (1999)
Schara, U., Zange, J., Napp, U., Shin, Y.S., Vorgerd, M., Mortier, W.: Diagnostische Probleme bei Glycogenose Typ III. Bioptische und 31Phosphor-MR-spektroskopische Befunde. Pädiat. Prax., 57, 227-236. (1999)
Wackerhage, H., Hoffmann, U., Essfeld, D., Leyk, D., Müller, K., Zange, J.: Recovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle. J. Appl. Physiol., 85, 2140-2158. (1998)
Grehl, T.,. Müller, K., Vorgerd, M., Tegenthoff, M., Malin, J.P., Zange, J.: Impaired aerobic glycolysis in muscle pfosphofructokinase deficiency results in biphasic post-exercise phosphocreatine recovery in 31P magnetic resonance spectroscopy. Neuromuscul. Disord., 8, 480-488. (1998)
Vesselova, T.N., Sintsyn, V.E., Bakharev, A.O., Karpov, Y.A., Ternovoy, S.K., Chasov, Y.E., Zange, J., Müller, K.: The use of 31P magnetic resonance of skeletal muscles in clinical cardiology: possibilities and prospects. Angiol. Vasc. Surg., 3, 20-32.(1997)
Zange, J., Müller, K., Schuber, M., Wackerhage, H., Hoffmann, U., Günther, R.W., Adam, G., Neuerburg, J.M., Sinitsyn, V.E., Bacharev, A.O., Belichenko, O.I. Changes in calf muscle performance, energy metabolism, and muscle volume caused by long term stay on space station Mir. Int. J. Sports Med., 18, S308-S309. (1997)
Wackerhage, H., Zange, J., Müller, K., Hoffmann, U., Essfeld, D.: Glycolytic ATP production during ischaemic exercise measured by 31P-MRS in vivo. Magma, 4, 151-155. (1996)
Zange, J., Müller, K., Gerzer, R., Sippel, K., Wehling, M.: Non-genomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise. J. Clin. Endocrinol. Metab., 81, 4296-4300. (1996)
Zange, J., Müller, K., Schuber, M., Günther, R.W., Adam, G., Neuerburg, J.M., Hoffmann, U., Wackerhage, H., Shenkman, B.S., Kozlovskaya, I.E., Sinitsyn, V.E., Bacharev, A.O., Belichenko, O.I. Changes in calf muscle performance, energy metabolism, and muscle volume caused by long term stay on space station Mir. ESA- SP-390, 287-290. (1996)
Schwarzbauer, C., Zange, J., Adolf, H., Deichmann, R., Nöth, U., Haase, A.: A Fast Mapping of Temperature Distributions by Rapid T1 Mapping, J. Magn. Reson., 106, 178-180. (1995)
Koop, J., Zange, J., Grieshaber, M.K.: Comparative investigations on the effect of invironmental salt stress on energy metabolism of amphipods estimated by 31P-NMR-spectroscopy and microcalometry. Termochim. Acta, 251, 45–51. (1995)
Zange, J., Müller, K., Schwarzbauer, C.: Application of magnetic resonance spectroscopy and imaging to problems in aerospace medicine. ESA-SP, 366, 523-524. (1993)
Zange, J., Gronczewski, J., Jans, A.W.H.: NH4+ metabolism and the intracellular pH in isolated perfused rat liver. Biochem. J., 293, 667-673. (1993)
Zange, J., Grieshaber, M.K., Jans, A.W.H.: The regulation of intracellular pH estimated by 31P NMR spectroscopy in the anterior byssus retractor muscle of Mytilus edulis L. J. Exp. Biol., 150, 95-109. (1990)
Zange, J., Pörtner, H.O., Jans, A.W.H., Grieshaber, M.K.: The intracellular pH of a molluscan smooth muscle during a contraction-catch-relaxation cycle estimated by the distribution of [14C]DMO and by 31P NMR spectroscopy. J. Exp. Biol., 150, 81-93. (1990),
Zange, J., Pörtner, H.O., Grieshaber, M.K.: The anaerobic energy metabolism in the anterior byssus retractor muscle of Mytilus edulis during contraction and catch. J. Comp. Physiol., 159, 349-358. (1989)