DLR - Institute of Aerospace Medicine - Jochen Zange, Institute of Aerospace Medicine

Staff

Dr.rer.nat. Jochen Zange

Dr.rer.nat. Jochen Zange
Team Leader of Working Group of Integrative Muscle Physiology

German Aerospace Center
Institute of Aerospace Medicine
Space Physiology
Linder Höhe
51147 Köln

Phone:+49 2203 601-3456
Mail:Jochen Zange
Internet:http://www.dlr.de/me

Education:
Study in Biology at the University of Duesseldorf (1979 - 1985)

Diploma in Biology:
1985: University of Duesseldorf, Subjects: Zoology, Plant Physiology, Organic Chemistry

Dr. rer. nat. in Biology:
1990, Heinrich-Heine-University Duesseldorf

Venia legendi (Privat-Dozent) in Physiolgy:
2006: Medical Faculty, University of Cologne

Professional Experience:

1988 - 1990	Scientist at the Max-Planck-Institute for Systems Physiology in Dortmund
1990-1991	Scientist at the Institute for Zoology, Dept. For Animal Physiology at the Heinrich-Heine-University Duesseldorf
seit 1991	Scientist at the Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne

Research Interest:

Physiology and Patho-physiology of the human skeletal muscle, non-invasive examinations on muscle contractility, energy metabolism, perfusion, and electro physiology, development and validation of countermeasures against muscle weakness using nutritional supplementation and training.

Publications:

Zange, J., Haller, T.,Müller, K., Liphardt, A.-M., Mester, J.: Energy metabolism in human calf muscle performing isometric plantar flexion superimposed by 20-Hz vibration, Eur. J. App. Physiol. 105(2): 265 - 270 (2009)
Zange, J., Mester, J., Heer, M., Kluge, G., Liphardt, A.-M.: 20-Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6° head down tilt bed rest, Eur. J. App. Physiol. 105(2): 271 - 277 (2009)
Zange J, Beisteiner M, Müller K, Shushakov V, Maassen N (2008) Energy metabolism in intensively exercising calf muscle under a simulated orthostasis. Pflügers Arch. 455 (6): 1153-1163
Vorgerd M, Zange J (2007) Treatment of glycogenosys type V (McArdle disease) with creatine and ketogenic diet with clinical scores and with 31P-MRS on working leg muscle. Acta Myol. 26: 59-61
Grehl, T., Fischer, S., Müller, K., Malin, J.P., Zange, J.: A prospective study to evaluate the impact of 31P-MRS to determinate mitochondrial dysfunction in skeletal muscle of ALS patients. Amyotroph. Lateral. Scler. 8(1), (2007), 4-8.
Schroers, A., Kley, R.A., Stachon, A., Horvath, R., Lochmüller, H., Zange, J., Vorgerd, M.: Gentamycin treatment in McArdle disease: Failure to correct myophosphorylase deficiency. Neurology 66, (2006), 285-286
Kornblum, C., Schröder, R., Müller, K., Vorgerd, M., Eggers, J., Bogdanow, M., Papassotiropoulos, A., Fabian, K., Klockgether, T., Zange, J.: Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study. Eur. J. Neurol, 12, (2005), 300–309.
Saft, C., Zange, J., Andrich, J., Müller, K., Lindenberg, K., Landwehrmeyer, B., Vorgerd, M., Kraus, P.H., Przuntek, H., Schöls, L.: Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease. Mov. Disord., 20(6), (2005): 674-679.
Schöls, L., Zange, J., Abele, M., Schillings, M., Skipka, G., Kuntz-Hehner, S., Van Beekvelt, M.C., Colier, W.N., Müller, K., Klockgether, T., Przuntek, H., Vorgerd, M. L-carnitine and creatine in Friedreich's ataxia. A randomized, placebo-controlled crossover trial. J. Neural. Transm., 112(6), (2005): 789-796.
Zange, J., Grehl, T., Disselhorst-Klug, C., Rau, G., Müller, K., Schröder, R., Tegenthoff, M., Malin, J.P., Vorgerd, M.: Breakdown of adenine nucleotide pool in fatiguing skeletal muscle in McArdle’s disease: a non-invasive 31P MRS and EMG study. Muscle Nerve, 27, (2003), 728-736.
Klasing, M., Zange, J.: In vivo quantitative near-infrared spectroscopy in skeletal muscle and bone during rest and isometric exercise. Proc. SPIE, (2003), in press
Zange, J., Kornblum, C., Müller, K., Kurtscheid, S., Heck, H., Schröder, R., Grehl, T., Vorgerd, M.: Creatine supplementation results in elevated phosphocreatine/adenosine triphosphate (ATP) ratios in the calf muscle of athletes but not in patients with myopathies. Ann. Neurol., 52, (2002), 126-127.
Vorgerd, M., Zange, J., Kley, R., Grehl, T., Hüsing, A., Jager, M., Müller, K., Schröder, R., Mortier, W., Fabian, K., Malin, J.P., Luttmann, A.: Effect of High-Dose Creatine Therapy on Symptoms of Exercise Intolerance in McArdle Disease: Double-blind, Placebo-Controlled Crossover Study. Arch. Neurol., 59, (2002), 97-101.
Vorgerd, M., Zange, J.: Carbohydrate oxidation disorders of skeletal muscle. Curr .Opin. Clin. Nutr. Metab. Care, 5, (2002), 611-617
Schöls, L., Vorgerd, M., Schillings, M., Skipka, G., Zange, J.: Idebenone in patients with Friedreich ataxia. Neurosci.Lett., 306, (2001), 169-172
Christ, M., Zange, J., Janson, C.P., Müller, K.,. Kuklinski, P., Schmidt, B.M.W., Tillmann, H.C., Gerzer, R., Wehling, M.: Hypoxia modulates rapid effects of aldosterone on oxidative metabolism in human calf muscle. J. Endocrinol. Invest., 24, (2001), 587-597.
Ziemssen, F., Sindern, E., Schröder, J.M., Shin, Y.S., Zange, J., Kilimann, M.W., Malin, J.P., Vorgerd, M. Novel missense mutations in the glycogen branching enzyme gene in adult polyglucosan body disease (APBD), Ann. Neurol., 47, (2000), 536-540.
Vorgerd, M., Schöls, L., Hardt, C., Ristow, M., Epplen, J.T., Zange, J.: Mitochondrial impairment of human muscle in Friedreich ataxia in vivo. Neuromuscul. Disord., 10, (2000), 430-435
Vorgerd, M., Grehl, T., Jäger, M., Müller, K., Freitag, G., Patzold, T., Bruns, N., Fabian, K., Tegenthoff, M., Mortier, W., Luttmann, A., Zange, J., Malin, J.P.: Creatine Therapy in Myophosphorylase Deficiency (McArdle Disease): A Placebo-Controlled Crossover Trial. Arch. Neurol., 57, (2000), 956-963.
Baerwalde, S., Zange, J., Müller, K., Maassen, N.: High-energy-phosphates measured by 31P-MRS during LBNP in exercising human leg muscle. J. Gravitat. Physiol., 6, (1999), P37-P38.
Schara, U., Zange, J., Napp, U., Shin, Y.S., Vorgerd, M., Mortier, W.: Diagnostische Probleme bei Glycogenose Typ III. Bioptische und 31Phosphor-MR-spektroskopische Befunde. Pädiat. Prax., 57, (1999), 227-236.
Wackerhage, H., Hoffmann, U., Essfeld, D., Leyk, D., Müller, K., Zange, J.: Recovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle. J. Appl. Physiol., 85, (1998), 2140-2158.
Grehl, T.,. Müller, K., Vorgerd, M., Tegenthoff, M., Malin, J.P., Zange, J.: Impaired aerobic glycolysis in muscle pfosphofructokinase deficiency results in biphasic post-exercise phosphocreatine recovery in 31P magnetic resonance spectroscopy. Neuromuscul. Disord., 8, (1998), 480-488.
Vesselova, T.N., Sintsyn, V.E., Bakharev, A.O., Karpov, Y.A., Ternovoy, S.K., Chasov, Y.E., Zange, J., Müller, K.: The use of 31P magnetic resonance of skeletal muscles in clinical cardiology: possibilities and prospects. Angiol. Vasc. Surg., 3, (1997), 20-32.
Zange, J., Müller, K., Schuber, M., Wackerhage, H., Hoffmann, U., Günther, R.W., Adam, G., Neuerburg, J.M., Sinitsyn, V.E., Bacharev, A.O., Belichenko, O.I. Changes in calf muscle performance, energy metabolism, and muscle volume caused by long term stay on space station Mir. Int. J. Sports Med., 18, (1997), S308-S309.
Wackerhage, H., Zange, J., Müller, K., Hoffmann, U., Essfeld, D.: Glycolytic ATP production during ischaemic exercise measured by 31P-MRS in vivo. Magma, 4, (1996), 151-155.
Zange, J., Müller, K., Gerzer, R., Sippel, K., Wehling, M.: Non-genomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise. J. Clin. Endocrinol. Metab., 81, (1996), 4296-4300.
Zange, J., Müller, K., Schuber, M., Günther, R.W., Adam, G., Neuerburg, J.M., Hoffmann, U., Wackerhage, H., Shenkman, B.S., Kozlovskaya, I.E., Sinitsyn, V.E., Bacharev, A.O., Belichenko, O.I. Changes in calf muscle performance, energy metabolism, and muscle volume caused by long term stay on space station Mir. ESA- SP-390, (1996), 287-290.
Schwarzbauer, C., Zange, J., Adolf, H., Deichmann, R., Nöth, U., Haase, A.: A Fast Mapping of Temperature Distributions by Rapid T1 Mapping, J. Magn. Reson., 106, (1995), 178-180.
Koop, J., Zange, J., Grieshaber, M.K.: Comparative investigations on the effect of invironmental salt stress on energy metabolism of amphipods estimated by 31P-NMR-spectroscopy and microcalometry. Termochim. Acta, 251, (1995), 45–51.
Zange, J., Müller, K., Schwarzbauer, C.: Application of magnetic resonance spectroscopy and imaging to problems in aerospace medicine. ESA-SP, 366, (1993), 523-524.
Zange, J., Gronczewski, J., Jans, A.W.H.: NH4+ metabolism and the intracellular pH in isolated perfused rat liver. Biochem. J., 293, (1993), 667-673.
Zange, J., Grieshaber, M.K., Jans, A.W.H.: The regulation of intracellular pH estimated by 31P NMR spectroscopy in the anterior byssus retractor muscle of Mytilus edulis L. J. Exp. Biol., 150, (1990), 95-109.
Zange, J., Pörtner, H.O., Jans, A.W.H., Grieshaber, M.K.: The intracellular pH of a molluscan smooth muscle during a contraction-catch-relaxation cycle estimated by the distribution of [14C]DMO and by 31P NMR spectroscopy. J. Exp. Biol., 150, (1990), 81-93.
Zange, J., Pörtner, H.O., Grieshaber, M.K.: The anaerobic energy metabolism in the anterior byssus retractor muscle of Mytilus edulis during contraction and catch. J. Comp. Physiol., 159, (1989), 349-358.