As part of the ICEXPOSE project, the cold, dry, remote and constantly ice-covered environment outside the Antarctic Concordia station will be used as an astrobiological test field to investigate the survival of selected microorganisms in an environment of extremely cold temperatures with temperature fluctuations around the freezing point and a highly variable UV radiation. For this purpose, the survivability of a variety of dormant, dried human (ICE-µHUMAN), space flight (ICE-SPACE) and extreme-environment (ICE-EXTREMO) associated microorganisms from all three domains of life in the closed exposure facility is EXPOSE, which has already been successfully deployed outside the ISS for space exposure times of up to 2 years. In the experimental platform, the microbiological reactions to individual and combined conditions, including simulation of astrobiologically relevant Martian atmosphere, are tested and, after the end of exposure, their survivability after various aspects is tested in the laboratory. With the results obtained, the international team of scientists wants to gain insights into how life in the frozen landscape on Mars or the icy moon of Jupiter, Europa, originated and could continue to exist. However, ICEXPOSE is also used to carry out preliminary tests for planned space experiments and to gain additional insights into already carried out.