Automated driving and electro-mobility are two of the key technologies for the future of road transportation. Automated driving has the potential to decrease road accidents due to human errors and to improve traffic flow, energy efficiency and passenger comfort. Electro-mobility is considered as a central component of a sustainable and climate friendly transportation system on the basis of renewable energies. The activities of the DLR Institute of System Dynamics and Control in the automotive field are mainly contributing to these technologies. We have been developing multifaceted innovative approaches for mechatronic X-by-Wire chassis aiming at the simultaneous improvement of energy efficiency, driving safety and comfort. Essential fields of research are the development of model- and AI-based control systems, with focus on motion planning, vehicle dynamics and chassis control, vehicle state estimation, model predictive full vehicle control, and active and semi-active suspension control, together with other core topics of electro-mobility. The latter comprise energy management, battery control and battery state estimation.