Metabolism and Human Performance
Regular physical activity and muscular exertion are essential for a healthy metabolism and for preserving muscle and bone function. In contrast, prolonged inactivity accelerates physical deconditioning and increases the risk of obesity, insulin resistance, and other metabolic disorders. These effects are not only relevant on Earth, but also play a critical role during extended stays in space. Our research aims to safeguard and enhance human health and performance in challenging environments through innovative, evidence-based strategies.
The department of Metabolism and Human Performance investigates the mechanisms underlying physical deconditioning, with the goal of identifying them at an early stage and developing effective countermeasures. Our research explores how physical activity and mechanical loading influence metabolic regulation and the health of the musculoskeletal system.
In-depth analyses of organ-specific metabolic processes – including mitochondrial function – and their systemic interactions, supported by genetic models, form the foundation for personalised, evidence-based interventions. By applying advanced non-invasive imaging techniques to diverse cohorts including patients with metabolic disorders as well as active and inactive older adults we can differentiate changes driven by inactivity from those primarily associated with ageing or disease.
We apply these findings to develop targeted training and nutrition strategies – ranging from maintaining astronauts’ physical fitness in space to promoting health and quality of life in older age and in chronic disease on earth. Our research takes a translational approach, bridging the gap from molecular mechanisms to practical applications in humans.
Working group
Translational Metabolic Research (Prof. Dr. Dominik Pesta)
- Clinical and translational aspects of energy metabolism, tissue-specific mitochondrial function, euglycemic-hyperinsulinemic clamp test, biosample management
- Non-invasive metabolic imaging of muscle and liver metabolism and advanced in vivo imaging for body composition assessment
Team
Training and countermeasures (Dr. Timo Frett)
- Studies on the effect of altered gravity conditions (e.g. short-arm centrifugation) on performance and trainability, development of training countermeasures